0742 Characteristics of the Low ArTH phenotype in patients with OSA

Abstract Introduction Obstructive sleep apnea (OSA) is a heterogenous disease with both anatomic and nonanatomic factors contributing to the pathophysiology. Recently low arousal threshold (ArTH) has been described in some patients there early evidence emerging that it could be clinical phenotype. The aim of this study was characterize phenotype large cohort confirmed by overnight polysomnography Methods setting community center. We performed retrospective review patient charts. included who underwent full-night diagnostic PSG. OSA defined as an hypopnea index (AHI) > 5. Epworth score, body mass (BMI), neck circumference, upper airway size using Modified Friedman (MF) were recorded. Low ArTH calculated AHI, fraction hypopneas O2 nadir.Abnormal narrowing MF >2. Large circumference ≥ 17 inches males or 16 females. Obesity BMI>30 kg/m2. Results 652 - 421(65%) male, 230 (35%) female. 299 (46%) had Mean age similar groups 54 +/- 14 vs 55 13 years. Male % less pronounced group (57% male 71% without ArTH; p<0.05). Patients lower percentage abnormal (53.5 62.6%, p<0.001), ( 64.6 78.8%, p<0.001) obesity (65.6 77.9%, p<0.001). Average BMI (34.8 8 36.9 8; p < 0.005), also (NC 16.5 1.8 17.4 respectively). sleepiness scale ArTh (10 11 9; 0.007) Conclusion describe phenotypic characteristics OSA. have BMI, Friedman. Further research studies should focus on whether are differences therapeutic responses phenotype, what might help clinicians more effectively detect Support (If Any) NA